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Telephone: 540-981-2105 or toll-free 800-981-2105
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Upon completing his training in Cardiology, Dr. Schmedtje joined the faculty of the University of Texas Medical Branch in Galveston, Texas as Assistant Professor and Medical Director of the Cardiac Care Unit in 1991. In 1998 he was appointed Associate Professor of Medicine and Director of Heart Failure Services at the Wake Forest University School of Medicine in Winston-Salem, North Carolina. In 2000, Dr. Schmedtje began building a private practice in Roanoke, Virginia, and in 2003, he founded the Roanoke Heart Institute. Dr. Schmedtje is currently Board Certified in the specialties of Internal Medicine, Cardiovascular Diseases, Echocardiography, Nuclear Cardiology and Cardiovascular Computed Tomography. He is formally recognized for his expertise by the Society for Cardiovascular Magnetic Resonance as well. He is a Fellow of the American College of Cardiology and the American Heart Association. Published Papers:
1. Schmedtje, J.F. Jr., Sax, S., Goldfarb, R., Pool, J.L., Nelson, E.B. "Localization of ectopic pheochromocytomas by magnetic resonance imaging." American Journal of Medicine, 1987; 83:770‑772.
2. Schmedtje, J.F. Jr., Oman, C.M., Letz, R., Baker, E.L. "Effects of scopolamine and dextroamphetamine on human performance." Aviation, Space and Environmental Medicine, 1988; 59:407‑410.
3. Schmedtje, J.F. Jr., Varghese, A., Gutkowska, J., Taylor, A.A. "Correlation of plasma norepinephrine and plasma atrial natriuretic factor during lower body negative pressure." Aviation, Space and Environmental Medicine, 1990; 61:555‑558.
4. Porter, T.R., Eckberg, D.L., Fritsch, J.M., Rea, R.F., Beightol, L.A., Schmedtje, J.F., Jr., Mohanty, P.K. "Autonomic pathophysiology in heart failure patients: sympathetic‑cholinergic interrelations." Journal of Clinical Investigation, 1990; 85:1362‑1371.
5. Schmedtje, J.F., Jr., Eckberg, D.L. "Preservation of oscillations in postocclusive reactive hyperemia." Journal of Applied Physiology, 1991; 70:363‑367.
6. Sorrell, V.L., Callaway, M.J., Zwischenberger, J.B., Schmedtje, J.F., Jr. "Left ventricular pseudoaneurysm." Journal of Thoracic Imaging, 1994; 9:258-259.
7. Schmedtje, J.F., Jr., Gutkowska, J., Taylor, A.A. "Reciprocity of hemodynamic changes during lower body negative and positive pressure." Aviation, Space and Environmental Medicine, 1995; 66:346-352.
8. Baykal, D., Schmedtje, J.F., Jr., Runge, M.S. “Role of the thrombin receptor in restenosis and atherosclerosis.” American Journal of Cardiology, 1995; 75:82B-87B.
9. Runge, M.S., Schmedtje, J.F., Jr., Horaist, C., Li, F., Wilcox, J.N., Bode, C. “New approaches to inhibiting thrombin’s effect on the blood vessel wall.” Fibrinolysis, 1995; 9(Suppl.1):69-73.
10. Schmedtje, J.F., Jr., Liu, W.-L., Taylor, A.A. "Cardiovascular deconditioning through bed rest leads to increased blood pressure variability and plasma renin activity." Aviation, Space and Environmental Medicine, 1996; 67:539-546.
11. Schmedtje, J.F., Jr., Liu, W.-L., Ji, Y.-S., Thompson, T.M., Runge, M.S. “Evidence of hypoxia-inducible factor-1 in vascular endothelial and smooth muscle cells.” Biochemical and Biophysical Research Communications, 1996; 220:687-691.
12. Stouffer, G.A., Schmedtje, J.F., Gulba, D., Huber, K., Bode, C., Aaron, J., Runge, M.S. “Restenosis following percutaneous revascularization - the potential role of thrombin and the thrombin receptor.” Annals of Hematology, 1996; 73:S39-S41.
13. Schmedtje, J.F., Jr., Liu, W.-L., Chen, Y. “pH is critical to the regulation of expression of the beta2-adrenergic receptor gene in hypoxia." Biochimica et Biophysica Acta, 1996; 1314:25-33.
14. Schmedtje, J.F., Jr., Ji, Y.-S., Liu, W.-L., DuBois, R.N., Runge, M.S. “Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells.” Journal of Biological Chemistry, 1997; 272:601-608.
15. Bode, C., Hanson, S.R., Schmedtje, J.F., Jr., Haber, E., Mehwald, P., Kelly, A.B., Harker, L.A., Runge, M.S. “Antithrombotic potency of hirudin is increased in nonhuman primates by fibrin targeting.” Circulation, 1997; 95:800-804.
16. Schmedtje, J.F., Jr. “Hypoxia and the vascular endothelium.” Fibrinolysis and Proteolysis, 1997; 11(Suppl.2):125-127.
17. Schmedtje, J.F., Jr. and Ji, Y-S. “Hypoxia and molecular cardiovascular medicine.” Trends in Cardiovascular Medicine, 1998; 8:24-33.
18. Ji, Y.-S. Xu, Q., Schmedtje, J.F., Jr., “Hypoxia induces HMG I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium.” Circulation Research, 1998; 83:295-304.
19. Schmedtje, J.F., Jr. "Commentary: Beta-blockers benefit patients with heart failure." ACP Journal Club 1999,130:29.
20. Xu, Q., Ji, Y.-S., Schmedtje, J.F., Jr. " Sp1 increases expression of cyclooxygenase‑2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure." Journal of Biological Chemistry, 2000; 275:24583-24589.
21. Schmedtje, J.F., Jr., Evans, G.W., Byerly, W., King, M., Goonan, K., Blastock-Glenn, C., Croft, J.B., Goff, D.C. “Treatment of congestive heart failure in a managed care setting: Baseline results from the Achieving Cardiac Excellence project.” North Carolina Medical Journal, 2003; 64:4-10.
Invited Book Reviews and Commentary:
1. Schmedtje, J.F., Jr. “The heart of the matter.” Re: Essential Atlas of Heart Diseases, Second Edition, Eugene Braunwald, ed. New York: McGraw-Hill. Lancet, 2002; 359:176.
2. Schmedtje, J.F., Jr. “Hearing is believing” Lancet, 2002; 359:1078.
3. Schmedtje, J.F., Jr. “A heartening tribute.” Re: Chou’s Electrocardiography in Clinical Practice, Fifth Edition, Borys Surawicz / Timothy K. Knilans, eds. Philadelphia: Saunders. Lancet, 2002; 359:1704.
4. Schmedtje, J.F., Jr. “Cardiovascular
medicine update.” Re: Evidence-based Cardiology, Second Edition, John A. Cairns,
John Camm, Ernest Fallen, Bernard Gersh, Salim Yusuf, eds. London: BMJ Books.
Lancet, 2003; 362:751.
1. Schmedtje, J.F., Schmedtje, J.F. Jr., Brahmie, Z. "Lymphokines and the lymphocyte clusters in the supranodular epithelium of the rabbit appendix." Anatomical Record, 1982; 202(3):169A.
2. Schmedtje, J.F. Jr., Oman, C.M., Letz, R., Baker, E.L. "A preliminary report on the effects of scopolamine and dextroamphetamine on human performance using computer based tests of memory and hand‑eye coordination." Proceedings of the Seventh International Man in Space Symposium, p. 49. Presented in Houston February 10, 1986.
3. Schmedtje, J.F. Jr., Taylor, A.A., Chelly, J.E., Davies, A.O., Peters, G.R., Mitchell, J.R. "Orthostatic tachycardia in man induced by the antidepressant drug, eclanamine." Clinical Research, 1987; 35:380A.
4. Schmedtje, J.F. Jr., Taylor, A.A., Chelly, J., Skinner, J.E., Gutkowska, J. "Changes in plasma atrial natriuretic factor levels associated with lower body negative pressure." Aviation, Space and Environmental Medicine, 1987; 58:491. Presented at the Annual Scientific Meeting of the Aerospace Medical Association (Las Vegas) May 11, 1987.
5. Taylor, A.A., Schmedtje, J.F. Jr., Skinner, J.E. "Changes in event related slow brain potentials associated with lower body negative pressure." Aviation, Space and Environmental Medicine, 1987; 58:496. Presented at the Annual Scientific Meeting of the Aerospace Medical Association (Las Vegas) May 12, 1987.
6. Schmedtje, J.F. Jr., Taylor, A.A., Chelly, J., Skinner, J.E., Gutkowska, J. "Effects of lower body negative pressure on plasma atriopeptins and evoked electroencephalo-graphic potentials." Proceedings of the Space Life Science Symposium: Three Decades of Life Science Research in Space, p. 111‑113. Presented in Washington, D.C. June 21, 1987.
7. Schmedtje, J.F. Jr., Taylor, A.A., Gutkowska, J. "Correlation of plasma atrial natriuretic factor levels with plasma norepinephine levels during lower body negative pressure." Aviation, Space and Environmental Medicine, 1988; 59:467. Presented at the Annual Scientific Meeting of the Aerospace Medical Association (New Orleans) May 9, 1988.
8. Schmedtje, J.F. Jr., Taylor, A.A. "Lower body negative pressure and selective phase shifts in hemodynamic variability." The FASEB Journal, 1989; 3:A231. Presented at the Annual FASEB Meeting (New Orleans) March 20, 1989.
9. Schmedtje, J.F. Jr., Eckberg, D.L. "Behavior of postocclusive periodic skin blood flow during baroreflex activation." Circulation, 1989; 80:II‑91. Presented at the 62nd Scientific Sessions of the American Heart Association (New Orleans) November 13, 1989.
10. Schmedtje, J.F. Jr., Eckberg, D.L. "Hemodynamic consequences of cardiovascular deconditioning: blood pressure variability." Clinical Research, 1990; 38:254A. Presented at the Annual Meeting of the American Federation for Clinical Research (Washington, D.C.) May 4, 1990.
11. Schmedtje, J.F. Jr., Eckberg, D.L., Nixon, J.V., Pippin, J.J., Taylor, A.A., Varghese, A. "Hemodynamic consequences of cardiovascular deconditioning: functional effects." Circulation, 1990; 82:III‑694. Presented at the 63rd Scientific Sessions of the American Heart Association (Dallas) November 15, 1990.
12. Schmedtje, J.F. Jr., Sung, S.S.J. "Development of a ribonuclease protection assay for human beta2‑adrenergic receptor messenger RNA." Clinical Research, 1991; 39:404A.
13. Schmedtje, J.F., Jr., Liu, W.-L., Taylor, A.A. "Cardiovascular deconditioning leads to increases in plasma renin activity and stress related plasma norepinephrine." The FASEB Journal, 1993; 7:A666. Presented at Experimental Biology `93 (New Orleans) April 1, 1993.
14. Schmedtje, J.F., Jr., Liu, W.-L. "Hypoxia can increase mammalian beta2-adrenergic receptor gene expression." Circulation, 1993; 88:I-191. Presented at the 66th Scientific Sessions of the American Heart Association (Atlanta) November 9, 1993
15. Schmedtje, J.F., Jr., Liu, W.-L., Chen, Y. "Beta2-adrenergic receptor density and mRNA are diminished by hypoxia and acidosis.” The FASEB Journal, 1995; 9:A108. Presented at Experimental Biology `95 (Atlanta) April 10, 1995.
16. Bode, C., Mehwald, P., Schmedtje, J.F., Jr., Harker, L.A., Hanson, S.R., Runge, M.S. “Enhanced antithrombotic potency of fibrin-targeted recombinant hirudin in a non-human primate model.” Circulation, 1995; 92:I-685. Presented at the 68th Scientific Sessions of the American Heart Association (Anaheim) November 15, 1995.
17. Schmedtje, J.F., Jr., Liu, W.-L., Runge, M.S. “Evidence of a hypoxia-inducible factor in vascular endothelial and smooth muscle cells.” Circulation, 1995; 92:I-749. Presented at the 68th Scientific Sessions of the American Heart Association (Anaheim) November 16, 1995.
18. Schmedtje, J.F., Jr., Liu, W.-L., Ji, Y.-S., DuBois, R.N., Runge, M.S. “Hypoxia induces cyclooxygenase-2 in vascular endothelium.” Presented at the William Harvey International Symposium on New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules” (New Orleans) April 15, 1996.
19. Schmedtje, J.F., Jr., Liu, W.-L., Ji, Y.-S., DuBois, R.N., Runge, M.S. “Hypoxia induces cyclooxygenase-2 in cultured vascular endothelial cells.” Presented at the 1996 Update in Thrombolysis International Symposium (Heidelberg, Germany) September 13, 1996.
20. Schmedtje, J.F., Jr., Ji, Y.-S., Liu, W.-L., DuBois, R.N., Runge, M.S. “Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells.” Circulation, 1996; 94:I-411. Presented at the 69th Scientific Sessions of the American Heart Association (New Orleans) November 12, 1996. Winner, Cournand and Comroe Young Investigator Prize in Cardiopulmonary and Critical Care.
21. Schmedtje, J.F., Jr., Ji, Y.-S., Liu, W.-L., DuBois, R.N., Runge, M.S. “Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor.” Presented at the Keystone Symposium on Inflammation, Growth-Regulatory Molecules and Atherosclerosis (Keystone, Colorado) January 21, 1997.
22. Schmedtje, J.F., Jr. “Hypoxia and the vasculature.” Presented at Cardiology Grand Rounds, Bowman Gray School of Medicine (Winston-Salem, North Carolina) January 29, 1997.
23. Schmedtje, J.F., Jr. “Hypoxia and the vascular endothelium.” Presented at the Cardiovascular Research Center Seminar, University of Virginia (Charlottesville) April 28, 1997.
24. Schmedtje, J.F., Jr. “Hypoxia and the vascular endothelium.” Presented at the Cardiovascular Physiology Seminar, Medical College of Virginia (Richmond) September 16, 1997.
25. Schmedtje, J.F., Jr., Xu, Q., Ji, Y.-S. “Hypoxia increases human endothelial prostaglandin E2: a potential mechanism for the patency of the ductus arteriosus.” Circulation, 1997; 96:I-5. Presented at the 70th Scientific Sessions of the American Heart Association (Orlando) on November 9, 1997.
26. Ji, Y.-S. Xu, Q., Schmedtje, J.F., Jr. “Hypoxia induces HMG I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium.” Circulation, 1997; 96:I-173. Presented at the 70th Scientific Sessions of the American Heart Association (Orlando) on November 10, 1997.
27. Schmedtje, J.F., Jr. “Hypoxia is a key regulator of endothelial function.” Presented at a symposium on Coronary Thrombosis and Atherosclerosis: Update on Theories, Trials and Treatment (Galveston, Texas) on December 4, 1997.
28. Schmedtje, J.F., Jr. "Hypoxia and cardiovascular cyclooxygenase-2." Presented at the Heart Failure Center Conference, Columbia-Presbyterian Medical Center (New York City) on October 5, 1998.
29. Schmedtje, J.F., Jr. "Cardiovascular diseases and cyclooxygenase-2." Presented at the Cardiovascular Research Conference, University of Louisville on December 10, 1998.
30. Schmedtje, J.F., Jr. "Cyclooxygenase-2 and the transcription factor Sp1 in cardiovascular hypoxia." Presented at the Keystone Symposia Conference on Inflammatory Paradigms and the Vasculature (Santa Fe) on February 26, 1999.
31. Xu, Q., Ji, Y.-S., Schmedtje, J.F., Jr. "Cellular hypoxia, cyclooxygenase-2, and Sp1: potential cofactors in heart failure." Journal of the American College of Cardiology, 1999; 33:172A. Presented at the American College of Cardiology 48th Annual Scientific Session (New Orleans) on March 7, 1999.
32. Schmedtje, J.F., Jr., Xu, Q., Busija, D.W. "Hypoxia induces cyclooxygenase-2 in the mouse." Presented at the American Heart Association Scientific Conference on Molecular, Cellular, and Integrated Physiological Approaches to the Failing Heart (Salt Lake City) on August 21, 1999.
33. Schmedtje, J.F., Jr. "Cyclooxygenase-2 and heart failure." Presented at the University of Rochester Cardiovascular Research Seminar Series (Rochester, NY) on December 17, 1999.
34. Schmedtje, J.F., Jr., Shelton, B., Byerly, W.G., King, M., Glenn, C.B., Goff, D.C., Jr. “Treatment of congestive heart failure in a managed care setting: baseline results from the Achieving Cardiac Excellence project.” Journal of Cardiac Failure, 2000; 6(Supp.2):82. Presented at the Heart Failure Society of America Scientific Meeting (Boca Raton) on September 12, 2000.
35. Schmedtje, J.F., Jr. “Cardiovascular cyclooxygenase-2 in hypoxia.” Invited Speaker, Keystone Symposium: Inflammatory Paradigms and the Vasculature (Steamboat Springs, Colorado) on April 12, 2002.
36. Schmedtje, J.F., Jr. “Biventricular pacing in heart failure” Presented at the Annual Meeting of the Virginia Chapter, American College of Cardiology (Charlottesville) on April 26, 2002.
37. Schmedtje, J.F., Jr., Goff, D.C., Jr., Evans, G.W., Duren-Winfield, V., Doss, D., Goonan, K.L., Janoski, A., Croft, J.B., “Improving heart failure care in the managed care setting. The Achieving Cardiac Excellence (ACE) project.” Journal of Cardiac Failure, 2002; 8: S98. Presented at the Heart Failure Society of America Scientific Meeting (Boca Raton) on September 24, 2002. 38. Schmedtje, J.F., Jr. “Chronic heart failure in the elderly.” Keynote address, Carilion Health System Annual Geriatric Medicine Conference, February 3, 2005. 39. Schmedtje, J.F., Jr. “Cardiovascular cyclooxygenase-2 in hypoxia.” Presented at the Keystone Symposium on Metabolic Syndrome and Cardiovascular Risk (Steamboat Springs, Colorado) on March 30, 2007. 40. Schmedtje, J.F., Jr. “Hypoxia regulates cardiovascular cyclooxygenase-2.” Presented at the Keystone Symposium on Molecular, Cellular, Physiological, and Pathogenic Responses to Hypoxia (Vancouver, B.C., Canada) on January 16, 2008. |
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